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Daily support for cellular energy.
The kind that lasts the whole day.
For the days that used to be easy and now need a second coffee and an earlier night. NAD+ at 500mg with quercetin and resveratrol from Japanese knotweed, in a two-capsule daily formula that supports cellular energy production and normal cellular repair.
- Steady, all-day energy — no caffeine, so nothing to crash off
- For the decade that starts to feel different from the one before it
- NAD+ at 500mg, quercetin at 250mg, resveratrol at 147mg
- Three ingredients, three declared amounts — no proprietary blend
- Third-party tested
- No proprietary blend
- Made in the U.S.A.
- Free shipping over $50
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- Third-party tested
- No proprietary blend
- Made in the U.S.A.
- Free shipping over $50
As Seen In
Nobody keeps the NAD+ they started with.
NAD+ is the coenzyme your cells use to turn food into usable energy, and it is not a fixed quantity. It falls steadily from early adulthood onward — in everyone, at roughly the same time of life, whatever else you are doing right.
Worth knowing
~50%
the fall in tissue NAD+ measured between early adulthood and midlife
The chart shows tissue NAD+ declining steadily and continuously from age 20 to age 60, ending at roughly half the level marked by the flat reference line at the top, which is labelled Age 20.
The decline is gradual, lifelong and universal. The dashed line marks the level you started from.
The curve is illustrative and not measured. Age-related NAD+ decline is well documented across human tissues — the roughly 50% figure comes from published measurements in human tissue, and the exact size of the fall varies by tissue and by study. Ageing is not a disease and is not something this or any supplement treats, prevents or reverses.
The same day costs more
What people notice first is almost never a lab value. It is that an ordinary day — work, gym, dinner, evening — takes more out of them than the identical day did ten years ago.
Recovery takes longer
One late night used to be free. Now it is billed the following afternoon, and sometimes the day after that as well.
Sharpness comes and goes
Names, words, the reason you walked into the room. Mostly fine, occasionally not, and more often in the second half of the day than the first.
It happens quietly
There is no moment when NAD+ drops. It declines by a few percent a year, which is slow enough that you compare yourself to last month and conclude nothing has changed.
So we built a daily formula for it. Three ingredients. One job.
Three ingredients. Three amounts. No blend.
Most of this category arrives as a proprietary blend with a long ingredient list and one total weight, which is the formulation equivalent of refusing to answer the question. You get a paragraph of impressive-sounding molecules and no way to know whether the one you came for is a real dose or a pinch.
This panel does not do that. Three actives, 900mg in total, each declared with its own amount: 500mg of NAD+, 250mg of quercetin from Japanese pagoda flower bud, and 150mg of Japanese knotweed root standardised to 98% resveratrol — 147mg of resveratrol itself. You can check every one of them against the research further down this page.
- NAD+ at 500mg per two-capsule serving — nicotinamide adenine dinucleotide, the coenzyme itself, declared with an exact amount rather than buried in a blend
- Quercetin at 250mg and resveratrol at 147mg — the two plant compounds studied alongside NAD+ biology, the resveratrol from 150mg of knotweed root standardised to 98%, at amounts that line up with the human research cited below
- One dose a day, with food — two capsules together, no timing to optimise and nothing to cycle off
- Cellular energy
- Healthy ageing
- Antioxidant support
Two capsules. Three jobs.
What each part of the formula is doing there.
Energy, at the source
NAD+ at 500mg — the coenzyme your mitochondria use to convert what you eat into ATP. This is the supply side of the formula, and it is the ingredient the product is named after.
Quercetin for the other side of the ledger
A flavonoid studied for its effect on CD38, the enzyme that consumes NAD+ and becomes more active with age. It supports a normal inflammatory response and normal immune function alongside it.
Resveratrol from Japanese knotweed
Knotweed root is where nearly all supplemental resveratrol comes from, and this extract is standardised to 98% of it. Studied for cardiovascular and cognitive support, and for its interaction with the sirtuin enzymes.
A routine you will actually keep
Two capsules with a meal, once a day. No loading phase, no cycling, no powder to weigh out, and nothing that has to be taken on an empty stomach at six in the morning.
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Three ingredients. Every amount printed.
Amounts are per two-capsule serving, taken directly from the Supplement Facts panel. There is no proprietary blend on this label, so there is nothing here that has to be described by its position in a list — including the capsule and the carriers, which are set out at the end.
Our promise
- Third-party tested
- No proprietary blend
- Made in the U.S.A.
- Non-GMO
And what isn't
- No proprietary blend
- No gelatin — the capsule is plant-derived HPMC
- No caffeine or stimulants
- No added sugar or artificial sweeteners
- No artificial colours or flavours
- No claim to slow, stop or reverse ageing
NAD+ (Nicotinamide Adenine Dinucleotide)
500mgThe coenzyme the product is named after, and the largest single amount on the panel. NAD+ is one of the most-used molecules in human biochemistry: it carries electrons through the reactions that turn food into ATP, and it is the substrate every sirtuin enzyme spends to do its job. It is also the molecule this whole category exists to talk about, which is why we declare it as an exact amount rather than as part of a blend.
Quercetin Dihydrate Extract
250mgSophora japonica
A flavonoid found in onions, apples and capers, and one of the most-studied plant compounds in human nutrition. This one is extracted from the whole flower bud of the Japanese pagoda tree, which is the richest commercial source of it and where most supplemental quercetin comes from. Two things put it on this panel. It supports a normal inflammatory response and normal immune function — the property most quercetin research is about. And it is studied as an inhibitor of CD38, the enzyme that breaks NAD+ down and that becomes markedly more active with age, which makes it a sensible partner for the ingredient above it rather than a filler.
Japanese Knotweed Extract
150mg — 98% resveratrolPolygonum cuspidatum
Knotweed root is the source nearly every resveratrol supplement and nearly every resveratrol trial uses; it concentrates resveratrol far more richly than grapes or wine do, and in this plant it occurs almost entirely as the trans- isomer that the human research used. The panel states the standardisation as well as the weight, which is the pair of numbers that actually tells you what you are getting: 150mg of extract at 98% works out at 147mg of resveratrol per serving. That is effectively the 150mg a day used in the RESHAW bone density trial, and it sits close to the 200mg used in the Witte memory and hippocampal connectivity study; both are cited below.
The capsule and the carriers
Other ingredientsPrinted here because a panel is only as honest as its second half. The capsule is HPMC — plant-derived cellulose rather than gelatin, so the product is suitable for vegetarians and vegans. The rest is microcrystalline cellulose, brown rice flour, olive oil, silicon dioxide and magnesium stearate: bulking agents, a flow agent and a lubricant, in the amounts it takes to fill a capsule consistently. The olive oil is the one worth noticing — quercetin and resveratrol are both better absorbed with fat present, which is also why the instruction is to take this with a meal.
Before you start
NAD+ is a dietary supplement. It is not a medicine, not an anti-ageing treatment, and not a substitute for medical advice. Quercetin and resveratrol both inhibit CYP3A4 and P-glycoprotein, which can raise blood levels of some prescription medications, including certain statins, calcium channel blockers, immunosuppressants and antifungals — talk to your doctor or pharmacist first if you take anything regularly. Resveratrol also has a mild antiplatelet effect, so take particular care if you use warfarin, a DOAC, clopidogrel or daily aspirin, and stop taking this at least two weeks before any scheduled surgery. Do not take it if you are pregnant or nursing, and speak to your clinician first if you have a hormone-sensitive condition, since resveratrol has weak phytoestrogenic activity. Keep out of reach of children. This product is not intended to diagnose, treat, cure or prevent any disease.
Nine papers this formula leans on.
Independent published research on NAD+ biology and on the individual ingredients — not trials of this product. gram has never run a clinical trial, and we would be sceptical of a supplement brand that told you otherwise.
Raising NAD+ in middle-aged and older adults — randomised crossover trial
A randomised, double-blind, placebo-controlled crossover trial in 30 adults aged 55 to 79, taking 1,000mg a day of nicotinamide riboside for six weeks. Blood cellular NAD+ rose roughly 60% against placebo, alongside a nearly fivefold increase in NAAD — a sensitive marker that the NAD+ pathway is being driven harder. No serious adverse events, and standard clinical laboratory markers stayed within normal ranges. Exploratory analysis found a reduction in systolic blood pressure of about 9 mmHg and reduced aortic stiffness in the participants who started with above-normal blood pressure.
Why it's here: The clearest human demonstration that oral supplementation moves the NAD+ pool this formula is built around.
NAD+ in aged human skeletal muscle — 21-day randomised crossover trial
A 21-day randomised, double-blind, placebo-controlled crossover trial in 12 men of median age 75, taking 1,000mg a day of nicotinamide riboside. It settled a previously open question by confirming that oral supplementation reaches human skeletal muscle: the muscle NAD+ metabolome marker NAAD doubled, blood NAD+ more than doubled, and methylation clearance products rose fivefold. Circulating pro-inflammatory cytokines IL-2, IL-5, IL-6 and TNF-α all fell significantly.
Why it's here: Muscle is the tissue most people mean when they talk about everyday energy, and this is where the NAD+ pathway was shown to reach it.
Why NAD+ falls with age — senescent cells and CD38+ macrophages
Published in Nature Metabolism in 2020, this work identified the mechanism behind age-related NAD+ decline rather than simply documenting it. Pro-inflammatory macrophages accumulate in visceral fat and liver with age, express high levels of the NAD+-consuming enzyme CD38, and drive NADase activity that lowers tissue NAD+. The inflammatory signals secreted by senescent cells are what induce those macrophages to proliferate and express CD38 in the first place — establishing a causal chain from cellular senescence through CD38 to falling NAD+.
Why it's here: This is the paper that explains why a formula for NAD+ contains a CD38-active flavonoid as well as NAD+ itself.
Quercetin, CD38 and exogenous NAD+ — synergistic inhibition study
Published in Cells in 2024, this study tested exogenous NAD+ with quercetin in human fibroblasts across two ageing models: UV photoageing and replicative senescence. Exogenous NAD+ alone triggered a 1.84-fold overexpression of CD38 — the enzyme that degrades it. Adding quercetin suppressed that CD38 upregulation by roughly 56%, and the combination raised the NAD+/NADH ratio 2.04-fold against control, cut UV-induced senescence by 37.9%, improved cell viability against UV damage by 24.4%, and extended replicative lifespan.
Why it's here: The most direct published work on the exact pairing this label uses: NAD+ and quercetin, together rather than separately.
Quercetin and blood pressure — systematic review and meta-analysis of RCTs
Published in the Journal of the American Heart Association, this meta-analysis pooled the randomised controlled trials of quercetin supplementation and found significant reductions in both systolic blood pressure, by about 3.04 mmHg, and diastolic blood pressure, by about 2.63 mmHg. The effect was dose-dependent: trials using 500mg a day or more showed significant reductions in both measures. Oral quercetin was safe and well tolerated across the trials reviewed, with no serious adverse events reported.
Why it's here: The largest pooled human dataset on quercetin, and the reason it is on a panel aimed at healthy ageing rather than at a single organ.
Isoquercetin and thromboinflammation — phase 2 randomised trial
A phase 2 randomised, double-blind, placebo-controlled trial in 46 adults, using 1,000mg a day of isoquercetin — the orally bioavailable glucoside form of quercetin — for 28 to 35 days. It significantly reduced whole-blood coagulability, attenuated collagen-induced platelet aggregation, inhibited plasma protein disulfide isomerase reductase activity, and suppressed inducible tissue factor gene expression in peripheral blood mononuclear cells. The compound was safe, well tolerated, and produced no off-target bleeding.
Why it's here: Confirms that quercetin is biologically active in humans at the level of inflammation and coagulation, not only in cell culture.
Resveratrol and bone mineral density in postmenopausal women — the RESHAW trial
A 24-month randomised, double-blind, placebo-controlled two-period crossover trial using resveratrol at 75mg twice daily — 150mg a day, effectively the amount this panel delivers. After 12 months, bone mineral density rose significantly at the lumbar spine and the femoral neck, alongside a 7.24% reduction in C-terminal telopeptide of type-1 collagen, an established bone resorption marker, against placebo. The gain at the femoral neck correlated with improved regional bone perfusion, pointing to a vascular mechanism, and the effect was most pronounced in participants who started with poorer bone health and in those also taking vitamin D and calcium.
Why it's here: The trial used 150mg of resveratrol a day; the knotweed extract on this label delivers 147mg.
Resveratrol, memory and hippocampal function in healthy older adults
A 26-week matched placebo-controlled trial in 46 healthy overweight adults aged 50 to 75, using 200mg a day of resveratrol. Retention of words over a 30-minute delay improved significantly against placebo, and functional connectivity increased between the left posterior hippocampus and the medial prefrontal cortex — a network central to memory consolidation. HbA1c and body fat both fell significantly and leptin rose. The memory improvements correlated with both the connectivity gains and the HbA1c reduction, suggesting the cognitive effect runs partly through glucose metabolism.
Why it's here: One of the few randomised trials to show a cognitive result from resveratrol in healthy adults, at a dose close to this one.
Resveratrol in the central nervous system — 52-week phase II trial
A 52-week phase II randomised, double-blind, placebo-controlled trial in 119 adults, escalating synthetic resveratrol to 2,000mg a day. Resveratrol was detectable in cerebrospinal fluid and was safe and well tolerated at high doses. It stabilised cerebrospinal fluid and plasma amyloid-β40, which declined significantly in the placebo group, and reduced CSF matrix metalloproteinase-9 by roughly 50%, consistent with preserved blood-brain barrier integrity and reduced neuroinflammation.
Why it's here: Establishes that oral resveratrol crosses into the central nervous system in humans and engages the SIRT1-linked pathways it is studied for.
Each citation describes independent published work on NAD+ biology or on a single ingredient. None of it is a trial of this product, none of it was funded by or conducted on behalf of gram, none of it establishes that this product will do anything in particular for you, and none of it concerns the treatment of any disease.
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Supply, drain, and what spends it.
NAD+ is not stored the way a vitamin is. It is made, spent and recycled continuously, so the level in a cell at any moment is the balance of three things: what comes in, what consumes it, and what work it is being spent on. The three ingredients on this panel map onto those three things in order — NAD+ itself on the supply side, quercetin on the enzyme that drains it, and resveratrol on the sirtuins that spend it.
That is the biochemistry these ingredients were chosen for, and why they are on one label rather than three. It is not a claim that this product changes any part of it in you.
900mg
of actives per two-capsule serving — 500mg NAD+, 250mg quercetin, 150mg knotweed extract at 98% resveratrol
7
sirtuins in human cells, and every one of them spends NAD+ to do its work
30
servings a bottle — two capsules, once a day, with food
- Step one
Take both with a meal
Resveratrol and quercetin are both fat-soluble enough that food helps, and capsules this size sit better on a full stomach. One dose a day, with whichever meal suits your routine. There is no benefit to splitting it and nothing to cycle off.
- Step two
The unglamorous inputs still win
Sleep, resistance training, not eating past the point of comfort, and staying off a second bottle of wine account for far more of how a decade goes than anything in a capsule. No supplement changes that ranking, and anything claiming to is selling you something worse than this.
- Step three
Judge it over months, not days
Nothing here works on a timescale you can feel by Thursday. If you want something more objective than a sense of how the afternoons are going, routine bloodwork before you start and again a few months in is the comparison worth having.
7 in 10
say the late afternoon is the part of the day that felt different first
Self-reported, gram customer survey, 2026. Illustrative placeholder — individual results vary, and this is not a clinical finding.
The first eight weeks.
A habit and tolerability timeline, not a results timeline. Nothing here promises a number will move, and nothing in this category works on the schedule the category likes to imply.
- Days 1–7
Find the meal it goes with
Take both capsules with food. Quercetin is the one most likely to be noticeable on an empty stomach, so if the first few days feel off, try a bigger meal before changing anything else.
- Weeks 2–3
The routine settles
Most people end up taking this alongside something they already take daily. That tends to be the easiest way to make it stick, and it is worth more than any timing optimisation.
- Weeks 4–6
Through the first bottle
If you have bloodwork or a procedure coming up, this is the point to mention the quercetin and resveratrol to whoever is arranging it — both affect drug metabolism, and resveratrol has a mild antiplatelet effect. Standard practice, whatever the brand on the bottle.
- Week 8+
Decide whether to continue
Eight weeks is long enough to know whether it has earned a place in your routine. If it has not, the guarantee is still open and there is nothing to send back.
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NAD+ vs. the typical longevity formula.
An illustrative comparison against common practice in a category that sells a promise nobody can keep. Read the panel on whatever you are considering — including this one.
gram NAD+
- Every ingredient declared with its own amount — no proprietary blend
- Resveratrol at 147mg — effectively the 150mg a day the RESHAW trial used
- States the extract weight, the standardisation, and the resveratrol it yields
- Independent research cited, with a link to every paper
- Explains why quercetin is on an NAD+ label, with the CD38 evidence
- Warns about the quercetin and resveratrol drug interactions
- Never claims to slow, stop or reverse ageing
- Third-party tested, COA published per batch
The typical longevity formula
- Every ingredient declared with its own amount — no proprietary blend
- Resveratrol at 147mg — effectively the 150mg a day the RESHAW trial used
- States the extract weight, the standardisation, and the resveratrol it yields
- Independent research cited, with a link to every paper
- Explains why quercetin is on an NAD+ label, with the CD38 evidence
- Warns about the quercetin and resveratrol drug interactions
- Never claims to slow, stop or reverse ageing
- Third-party tested, COA published per batch
60-day money-back guarantee · Free shipping over $50
Back Guarantee
Sixty days. Then decide.
Take NAD+ every day for 60 days. If it hasn’t earned a place in your routine, email us and we’ll refund the order — including bottles you’ve already opened.
We’d rather carry the risk than ask you to.
- Full refund within 60 days, opened bottles included
- No form to fill in — one email does it
- Cancel or pause a subscription any time
60-day money-back guarantee · Free shipping over $50
What people say about NAD+
The afternoons came back
“I am 54 and the 3pm wall had become a fixed appointment. Somewhere in the second month I noticed I had stopped scheduling around it. I cannot prove it was this, but I reordered.”
Finally a label I can read
“Every other product I looked at gave me a blend name and one total weight. This one tells me exactly how much of each thing I am taking. That is the entire reason I switched.”
No jitters, no crash
“I came off a pre-workout that was mostly caffeine and was braced for a flat few weeks. It was fine. Steadier, if anything, and I sleep better than I did on the other thing.”
Cheaper than the injections
“A clinic near me wanted four figures for a course of NAD+ IVs. I decided to try the unglamorous version first. Six months later I have not booked the drip.”
My pharmacist checked it
“I take a statin and wanted to be sure. I brought the label in, she looked at the quercetin and resveratrol, and told me what to watch for. The fact the page told me to ask is why I trusted it.”
Questions worth asking.
I take prescription medication. Can I take this?
Will this make me live longer?
Why is quercetin in an NAD+ product?
The label says 150mg of knotweed extract. How much resveratrol is that?
When should I take it, and can I take it with my other supplements?
Can I take this if I am pregnant, nursing, or have a hormone-sensitive condition?
Is it vegan? What is the capsule made of?
What does “third-party tested” actually mean here?
What if it isn’t for me?
Start with one bottle.
Sixty days to decide, free shipping over $50, and a subscription you can pause in one click.
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