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Your liver handles everything you throw at it.
This is daily support for work it already does.
Every drink, every big meal, every late night, every course of medication — all of it lands on the same organ, and it gets on with the job without ever mentioning it. Turmeric, beetroot, dandelion and milk thistle, in a two-capsule daily formula for liver function that is already normal.
- Two capsules a day, for the one organ that never gets one off
- Turmeric at 300mg and beetroot at 200mg, with artichoke standardised to 5% cynarin
- Eight ingredients, eight declared amounts — no proprietary blend
- Not a cleanse, not a flush, and not a fourteen-day kit
- Third-party tested
- No proprietary blend
- Made in the U.S.A.
- Free shipping over $50
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- Third-party tested
- No proprietary blend
- Made in the U.S.A.
- Free shipping over $50
As Seen In
Nobody’s week is evenly distributed.
Three quiet days, a long Thursday, a Friday that turns into a Saturday. Everything you eat, drink and take goes through one organ — and that organ does not get to average the week out the way the rest of you does.
Worth knowing
1 in 3
U.S. adults carry more fat in the liver than is considered normal
The chart shows a week of liver workload: flat from Monday through Wednesday, rising on Thursday, peaking across Friday and Saturday, then dropping on Sunday to below the flat reference line, which marks an ordinary Tuesday.
Two days carry most of the week, and the organ handling them has no way to move any of it onto a quieter one. The dashed line marks an ordinary Tuesday for comparison.
The weekly curve is illustrative and not measured. The 1-in-3 figure is NHANES population data on excess liver fat among U.S. adults; it describes a population, not a gram customer. Nothing on this page treats, prevents or reverses fatty liver disease or any other liver condition — if you have one, or your liver enzymes have come back high, the person to talk to is your doctor.
It never gets a day off
Your liver runs several hundred jobs at once and stops for none of them — clotting factors, bile, cholesterol, hormones, and everything you swallow. There is no quiet season and no queue.
The weekend costs more than you think
Two nights out, a takeaway, a late finish and a lie-in all land on the same organ inside about forty-eight hours. Your calendar treats them as separate events. Your liver does not.
You can’t feel it working
The liver has no pain nerves of its own. Nothing about how a week felt tells you much about how the week went for it, which is exactly why this whole category leans so hard on the word sluggish.
It adds up quietly
Changes in the liver happen over years without symptoms. A liver panel at your annual physical is the only reliable way to know where yours sits — and it costs almost nothing to ask for one.
So we built a daily formula for it. Eight ingredients. Eight amounts.
Eight ingredients. Eight amounts. No blend.
Almost everything sold in this category arrives as a proprietary blend, which is the formulation equivalent of refusing to answer the question. You get one total weight for a list of impressive-sounding plants, and no way to know whether the one you cared about is 400mg or a pinch.
This panel does not do that. All eight ingredients are declared individually — 300mg of turmeric, 200mg of beetroot, 100mg of dandelion, 50mg each of artichoke, ginger and milk thistle, 20mg of alfalfa and 10mg of L-cysteine. You can check every one of them against the research further down this page, including the places where ours is the smaller number.
- 780mg of botanicals per two-capsule serving — across eight ingredients, every one declared with its own amount, because there is no blend to hide one inside
- Artichoke standardised to 5% cynarin — 50mg delivering 2.5mg of cynarin, the only standardised extract on this panel and the ingredient with the strongest trial behind it
- Not a cleanse, a flush or a detox — your liver already does this continuously; this is a daily formula for normal liver function, and it does not treat any liver condition
- Normal liver function
- Bile and digestion
- Antioxidant support
Two capsules. Four parts.
Why each part of the formula is in there.
The bitter side
Artichoke and dandelion, the two traditional bitters on this panel. Both have a long history in European herbal practice around bile flow and digestive comfort after a heavy meal, and artichoke is the one ingredient here with a proper randomised trial behind it.
The antioxidant side
Turmeric at 300mg and ginger at 50mg, the two most-studied culinary roots in this area. Both are in the formula for antioxidant support rather than for any promised effect on a lab value.
The two you came for
Milk thistle and beetroot are the names that put most people in this aisle. Both are here, both are declared to the milligram, and the ingredients section below is honest about how our amounts compare with the ones in the trials.
A simple routine
Two capsules with food, once a day. Hypromellose capsule, brown rice flour, nothing else — no splitting the dose and nothing to time around the rest of your day.
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Eight ingredients, every one declared to the milligram.
Amounts are per two-capsule serving, taken directly from the Supplement Facts panel. There is no proprietary blend on this label, so there is nothing here we could round off or leave vague even if we wanted to.
Our promise
- Third-party tested
- Every amount declared
- Made in the U.S.A.
- Vegan capsule
And what isn't
- No proprietary blend — every amount is printed
- No piperine or black pepper extract
- No senna, cascara or other laxative herbs
- No gelatin — hypromellose capsule
- No artificial colours or flavours
- No claim to cleanse, flush or reverse anything
Turmeric Powder (root)
300mgCurcuma longa
The largest single amount on the panel, and whole root powder rather than a curcumin extract. Turmeric root is roughly 2–5% curcuminoids by weight, so 300mg of powder carries somewhere around 6 to 15mg of them — culinary territory, and far below the 500mg to 3,000mg of curcumin used in the trials cited below. That is deliberate on a liver product. Turmeric is now the most common cause of clinically apparent herbal-related liver injury in the United States, and the reported cases involve concentrated extracts and bioavailability enhancers rather than root powder. There is no piperine in this formula for the same reason.
Beet Root Powder
200mgBeta vulgaris
Whole root powder, for the betaine and the nitrates. Betaine is a methyl donor the liver uses in homocysteine metabolism, and beetroot nitrate is what the blood-flow research is about. The trial below used 250mL of beetroot juice a day, which is a great deal more beetroot than 200mg of powder. It is also the reason for the FAQ about pink urine, which is harmless and more common than most people expect.
Dandelion Powder (leaf)
100mgTaraxacum officinale
Note the parenthesis on the panel: leaf, not root. Most of the traditional liver and bile literature concerns the root; the leaf is the traditional bitter and the traditional diuretic — the French name for the plant is a joke about precisely that. Either way the human evidence is thin. The 2025 review cited below is candid that the work supporting dandelion is preclinical, and we would rather link to a review that says so than one that doesn’t.
Artichoke Extract (whole herb)
50mg, standardised to 5% cynarinCynara scolymus
The only standardised extract on this label, and the ingredient the formula is really built around. 50mg at 5% gives 2.5mg of cynarin per serving. The 2018 randomised trial below used 600mg of artichoke leaf extract a day, standardised to deliver about 6mg of cynarin, in three divided doses rather than one — more than twice what this serving provides. Cynarin and the related caffeoylquinic acids are what the choleretic and lipid research is about.
Ginger Powder (root)
50mgZingiber officinale
The best-tolerated anti-nausea botanical there is, and part of why a bitter formula like this one sits reasonably well on the stomach. The NAFLD trial below used 2g a day — forty times this amount — so treat the 50mg here as a formulation choice rather than a research dose. Ginger has a mild antiplatelet effect at higher intakes, which matters if you take an anticoagulant.
Milk Thistle Powder
50mgSilybum marianum
The name most people came here for, and the entry we are most exposed on. This is whole powder with no silymarin standardisation stated, whereas the trials run on silymarin extracts at 140mg to 420mg a day and the large NASH trial used 700mg three times daily. Milk thistle seed is roughly 1.5–3% silymarin, so 50mg of powder is not in the same range as any of that. It is on the panel; it is not the dose the research used, and we are not going to imply otherwise.
Alfalfa Powder (leaf)
20mgMedicago sativa
A traditional green with the thinnest evidence on this panel — it is here as a chlorophyll and micronutrient inclusion, not for a documented liver effect. Two things are worth knowing anyway: alfalfa leaf carries vitamin K, which is the interaction that matters if you take warfarin, and alfalfa is traditionally avoided in autoimmune conditions because of its L-canavanine content. At 20mg both are small considerations, but they are the kind we would rather print than omit.
L-Cysteine Hydrochloride
10mgThe smallest amount on the panel, and the one most likely to be over-sold elsewhere. Cysteine is the rate-limiting amino acid for making glutathione, which is the liver’s principal antioxidant — that part is real biochemistry. What is not real is 10mg mattering much next to the roughly one gram of cysteine a normal day’s protein already supplies, or the 1,200mg of N-acetylcysteine used in the NAFLD work. If glutathione support is specifically what you are after, buy NAC as a single ingredient.
The honest weakness of this label
Artichoke is the only standardised extract here. The other seven are whole powders, and for turmeric, milk thistle, ginger and beetroot our amount sits well below the amount used in the research on this page — in milk thistle’s case by a wide margin. That is a real limitation of a formula built around eight ingredients in two capsules rather than one ingredient at a research dose. We would rather you read it here than work it out from the panel afterwards. If a single botanical at a studied dose is what you want, buy that botanical on its own.
Before you start
Liver Support is a dietary supplement. It is not a medicine, not a treatment for fatty liver disease, hepatitis, cirrhosis or any other liver condition, and not a substitute for medical advice. Do not take it if you have gallstones or a bile duct obstruction: artichoke, dandelion and turmeric are all choleretic, and increasing bile flow against an obstruction is genuinely dangerous. Turmeric is a documented cause of rare idiosyncratic liver injury — the reported cases involve concentrated extracts rather than the root powder used here, but if you have ever reacted to a turmeric supplement, do not take this one. Talk to your doctor before using it if you take warfarin or another anticoagulant, as turmeric and ginger have mild antiplatelet effects and alfalfa carries vitamin K. Artichoke, dandelion and milk thistle belong to the daisy family, so avoid this formula if you are allergic to ragweed or related plants. Do not take it if you are pregnant or nursing. Stop before any scheduled surgery, and tell your doctor you take a turmeric-containing supplement if your liver enzymes are being monitored. This product is not intended to diagnose, treat, cure or prevent any disease.
Six papers this formula leans on. And one that argues with it.
Independent published research on individual ingredients — not trials of this product. gram has never run a clinical trial, and we would be sceptical of a supplement brand that told you otherwise.
Artichoke leaf extract in non-alcoholic fatty liver disease — randomised controlled trial
A two-month double-blind, placebo-controlled trial in 100 adults with ultrasound-diagnosed NAFLD, ninety of whom completed it, using 600mg of artichoke leaf extract a day in three divided doses. ALT fell by 20.0 U/L in the artichoke group while rising 4.5 on placebo; AST fell 11.2 against a rise of 3.8. Doppler sonography showed increased hepatic vein flow, reduced portal vein diameter and reduced liver size, and ultrasound-graded severity improved in 81.6% of the artichoke group versus 5.0% on placebo. Total cholesterol, LDL and triglycerides all fell. No adverse events were reported.
Why it's here: Artichoke is the only standardised extract on our panel, and this is the trial the formula is built around.
Silymarin in NAFLD and NASH — systematic review and meta-analysis
A 2024 review in Annals of Hepatology pooling 26 randomised controlled trials in 2,375 patients. Silymarin was associated with reduced ALT and AST, alongside reductions in total cholesterol, triglycerides, LDL, fasting insulin and HOMA-IR, and an increase in HDL. Fatty liver index and fatty liver score both fell, and where liver histology was available it showed significantly improved hepatic steatosis in the intervention groups.
Why it's here: Milk thistle is on our panel at 50mg of whole powder. These trials used silymarin extracts, typically at 140mg to 420mg a day.
Curcumin and liver enzymes in NAFLD — GRADE-assessed meta-analysis
A systematic review and meta-analysis of 14 randomised trials in 778 people with NAFLD, using curcumin at 50mg to 3,000mg a day over 8 to 12 weeks. Pooled results showed a reduction in ALT of 8.72 U/L (95% CI −15.16 to −2.27) and in AST of 6.35 U/L (95% CI −9.81 to −2.88). Alkaline phosphatase did not move significantly overall. The evidence was graded moderate for all three markers, and doses under 1,000mg a day outperformed higher ones for AST.
Why it's here: Turmeric is the largest single amount on our panel, though as root powder rather than the concentrated curcumin these trials used.
Ginger supplementation in NAFLD — randomised, double-blind, placebo-controlled pilot
Forty-four adults with NAFLD took 2g of ginger a day or placebo for twelve weeks, both groups also receiving diet and activity counselling. ALT fell significantly against placebo, as did GGT, HOMA-IR, hs-CRP and TNF-α, and CAP-measured hepatic steatosis fell from 307.8 to 255.8 in the ginger group against 287.5 to 276.4 on placebo. AST and fibrosis score did not differ significantly between the groups.
Why it's here: Ginger is on our panel at 50mg — a fortieth of the amount used here, and included for tolerability as much as for anything else.
Beetroot juice and the Mediterranean diet in NAFLD — randomised controlled trial
A 2023 trial in Frontiers in Nutrition randomising 180 adults with NAFLD across four arms for twelve weeks: control, 250mL of beetroot juice daily, a Mediterranean diet, or both together. Liver enzymes, total cholesterol, triglycerides and LDL fell significantly in all three treatment arms and HDL rose, with sonographic hepatic steatosis reduced in the beetroot arms. The combination arm performed best.
Why it's here: Beetroot is the second-largest amount on our panel, at 200mg of whole root powder.
Dandelion and liver health — 2025 review of the hepatoprotective evidence
A review of what is actually known about Taraxacum officinale and the liver. The preclinical work is reasonably consistent: extracts protect against chemically induced liver damage in animals, and intraduodenal dandelion extract increased bile volume by roughly a third in rats. The review is equally clear that human clinical studies of its hepatoprotective effects remain limited, and that controlled trials in people are needed before any of it can be called established.
Why it's here: Dandelion is 100mg of our panel. We are citing the review that says the human evidence isn’t there yet, because that is the honest state of it.
Turmeric and liver injury — NIH LiverTox review
The federal review of the turmeric hepatotoxicity evidence, and the paper that argues against an ingredient in this formula. LiverTox gives turmeric a likelihood score of A — a well-documented cause of clinically apparent liver injury — with a typical latency of one to four months and a strong association with the HLA-B*35:01 allele, carried by over 70% of cases against 10–15% of controls. The reported cases cluster around concentrated products, commonly 500mg of turmeric or 1,000mg of curcumin daily taken with black pepper, and the outbreaks are linked to enhanced-bioavailability formulations. Estimated incidence is 1 in 10,000 to 1 in 100,000 people exposed.
Why it's here: Turmeric is 300mg of our panel, as root powder and with no piperine. This paper is why it is root powder, why there is no piperine, and why the safety note says what it says.
Each citation describes published work on a single ingredient, at the dose used in that work — which in most of these cases is larger than the amount used here, and in none of them smaller. None of it establishes that this product will do anything in particular for you, none of it was funded by or conducted on behalf of gram, and none of it concerns the treatment of any disease.
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Two phases and a drain.
Everything absorbed from your gut arrives at the liver before it reaches the rest of you. What happens there runs in two broad phases: a first set of enzyme reactions that makes a compound chemically reachable, and a second that attaches something water-soluble to it so it can leave — through bile into the gut, or through the blood to the kidneys. The bile route is the one bitter botanicals have traditionally been used around, and it is why artichoke and dandelion are on this panel.
That is the biochemistry these ingredients were chosen for. It is not a claim that this product changes any part of it in you, and it is emphatically not a claim that any of it needs unblocking.
780mg
of botanicals per two-capsule serving, across eight individually declared ingredients
2.5mg
of cynarin per serving, from the one standardised extract on the panel
1.5L
of blood through the liver every minute — roughly a quarter of what the heart pumps
- Step one
Take both with food
Bitter botanicals do their traditional work around a meal, and turmeric and ginger sit better on a full stomach than an empty one. One dose a day, with whichever meal suits your routine. There is no benefit to splitting it.
- Step two
The obvious things still matter more
Alcohol, body weight, sleep and what you eat account for the overwhelming majority of the load on your liver. No supplement changes that ranking, and anything claiming to is selling you something worse than this.
- Step three
A blood test is the only way to know
ALT, AST, ALP and GGT make up the standard liver panel, and they cost very little to add to routine bloodwork. How your week felt will tell you nothing useful — the organ has no pain nerves and no opinion.
3 in 4
say they started this after a blood test result, not because they felt anything
Self-reported, gram customer survey, 2026. Illustrative placeholder — individual results vary, and this is not a clinical finding.
The first eight weeks.
A habit and tolerability timeline, not a results timeline. Nothing here promises a number will move; a liver panel is the only thing that can tell you that.
- Days 1–7
Find the meal it goes with
Take both capsules with food. If your urine or stools turn pink in the first few days, that is the beetroot and it is harmless — there is an FAQ about it below. Bitters can also be noticeable on an empty stomach, so try a bigger meal before changing anything else.
- Weeks 2–3
The routine settles
Most people end up taking this alongside something they already take daily. That tends to be the easiest way to make it stick, and it is worth more than any timing optimisation.
- Weeks 4–6
Through the first bottle
If you have bloodwork coming up, this is the sensible point to ask for a liver panel — and to tell whoever orders it that you take a turmeric-containing supplement, which is standard practice worth following whatever the brand on the bottle.
- Week 8+
Decide whether to continue
Eight weeks is long enough to decide. If you had a liver panel before you started and can get one now, that comparison is the most useful thing you will have — considerably more useful than how the eight weeks felt.
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Liver Support vs. the typical liver formula.
An illustrative comparison against common practice in a category that mostly sells a metaphor. Read the panel on whatever you are considering — including this one.
gram Liver Support
- Every ingredient declared with its own amount — no proprietary blend
- States the cynarin standardisation, and what the trial used
- Says outright where our amounts sit below the studied doses
- Independent research cited, with a link to every paper
- Cites the turmeric liver-injury evidence on a turmeric product
- Warns about gallstones, bile duct obstruction and warfarin
- Never calls itself a cleanse, a flush or a detox
- Third-party tested, COA published per batch
The typical liver formula
- Every ingredient declared with its own amount — no proprietary blend
- States the cynarin standardisation, and what the trial used
- Says outright where our amounts sit below the studied doses
- Independent research cited, with a link to every paper
- Cites the turmeric liver-injury evidence on a turmeric product
- Warns about gallstones, bile duct obstruction and warfarin
- Never calls itself a cleanse, a flush or a detox
- Third-party tested, COA published per batch
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Sixty days. Then decide.
Take Liver Support every day for 60 days. If it hasn’t earned a place in your routine, email us and we’ll refund the order — including bottles you’ve already opened.
We’d rather carry the risk than ask you to.
- Full refund within 60 days, opened bottles included
- No form to fill in — one email does it
- Cancel or pause a subscription any time
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What people say about Liver Support
Bought it for the label
“I have read a lot of liver supplement pages and they all say the same nothing. This one told me the milk thistle was lower than the trials use. First time a brand has argued against itself in front of me, so I bought it.”
Sits fine with a meal
“Bitter formulas usually give me trouble. This one is fine as long as I take it with lunch rather than with coffee. Two capsules, done, no aftertaste.”
Pink urine, briefly alarming
“Nobody warned me about the beetroot — well, the page did, I just hadn’t read that far. Two days of pink and then I found the FAQ. Would have panicked otherwise.”
My GP didn’t object
“Took the bottle to my appointment half expecting to be told to bin it. She read the panel, said the turmeric was low enough not to worry about, and told me to keep the annual bloods going. Fair enough.”
Replaced three bottles
“I was taking milk thistle, turmeric and a beetroot powder separately and losing track of all three. One bottle is easier to actually keep up with, even if the amounts are smaller.”
Questions worth asking.
Is this a detox or a cleanse?
Turmeric has been linked to liver injury. Why is it in a liver supplement?
Why is there beetroot in it, and will it turn my urine pink?
The milk thistle is only 50mg. Isn’t that low?
I take medication or have gallstones. Can I take this?
When should I take it, and can I take it with my other supplements?
What does “third-party tested” actually mean here?
What if it isn’t for me?
Start with one bottle.
Sixty days to decide, free shipping over $50, and a subscription you can pause in one click.
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