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The part your GLP-1 doesn’t cover.
Energy, digestion and nutrition.
Your appetite is down and the weight is coming off. The tiredness, the queasy mornings and the shedding that so often come with it are what this is for — ginger and enzymes for digestive comfort, with the B12, folate, iron and zinc a much smaller plate stops delivering. It is not a GLP-1 medication and it is not a substitute for one.
- Steadier energy through the months your intake is down
- Ginger, peppermint and enzymes for a slower, heavier stomach
- Full-dose B12, folate, iron and zinc — the nutrients that fall first
- Designed to sit alongside your prescription, never to replace it
- Third-party tested
- Standardised branded actives
- Made in the U.S.A.
- Free shipping over $50
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- Third-party tested
- Standardised branded actives
- Made in the U.S.A.
- Free shipping over $50
As Seen In
Eating less means taking in less of everything.
A GLP-1 medication turns appetite down, slows the stomach and shrinks the plate. Your vitamin and mineral requirements do not change with it — they are the same on 1,200 calories a day as they were on 2,400.
The gap
1 in 5
GLP-1 users are newly diagnosed with a nutritional deficiency within twelve months
The chart shows nutrient intake declining steeply over the first six months and then drifting lower, measured against a flat reference line marked “What your body still needs”.
Intake drops quickly and then keeps drifting down. The requirement stays flat. The gap between the two is what this formula is for, and it widens the longer you are on treatment.
Figure is illustrative. The deficiency rate reflects published cohort data on GLP-1 users, not a gram study, and describes the population rather than any individual.
Smaller plate, same requirement
Micronutrient needs are set by your physiology, not by your appetite. Halve the food and you halve the intake, while the requirement stays exactly where it was.
The gut slows down
Delayed gastric emptying is part of how these medications work. It is also why nausea, reflux and constipation are the side effects people report most in the first months.
Hair is often the first sign
Shedding after rapid weight loss is the side effect people mention least and mind most. Zinc and iron are among the few nutrients you can actually do something about.
The tiredness adds up
Low B12, folate, iron and magnesium all show up as tiredness, and they tend to arrive together. It usually gets blamed on the medication when a good share of it is the diet underneath.
So we built the nutrition half. Steadier energy, calmer digestion.
The nutrition half of a GLP-1 protocol.
Your prescription handles appetite, and it handles it well. Nothing about it replaces what a much smaller appetite stops delivering, and nothing about it settles a stomach now emptying at half speed. That is the job this was built for — the unglamorous half nobody writes a prescription for.
Two capsules carry both sides: ginger, peppermint, bromelain and a five-enzyme complex for digestion; methylcobalamin B12, L-5-MTHF folate, P-5-P B6, chelated iron and zinc, magnesium and D3 for replenishment — with BioPerine® black pepper extract to help you absorb them.
- 525mcg methylcobalamin B12 and 400mcg DFE folate as L-5-MTHF — both active forms, no conversion step
- 18mg iron and 20mg zinc as bisglycinate chelates — the forms chosen for tolerability, not for label weight
- Not a GLP-1 medication — it doesn’t mimic one, replace one, or let you take less of one
- Digestive comfort
- Nutrient replenishment
- Everyday energy
Two capsules. Two jobs.
Every vitamin and mineral below is printed with an exact amount on the panel, so you can add it to whatever else you take and check the totals.
Digestive comfort
Ginger standardised to its gingerol content, with peppermint leaf and bromelain — the traditional trio for a stomach that is emptying slowly and letting you know about it.
Nutrient replenishment
525mcg of methylcobalamin B12, 400mcg DFE of L-5-MTHF folate and 26mg of P-5-P B6, plus chelated iron, zinc and D3 — the nutrients that fall first when intake drops.
Enzymes and cultures
A five-enzyme complex covering starch, protein, fat, fibre and lactose, alongside 6 billion CFU of shelf-stable Bacillus coagulans spores.
Steadier days
Magnesium at 200mg and ashwagandha standardised to 5% withanolides, for the sleep, muscle function and stress load a fast weight change puts pressure on.
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Eight nutrients at full dose. Three blends, named.
Amounts are per two-capsule serving, taken directly from the Supplement Facts panel. Where something reads low, we say it reads low.
Our promise
- Third-party tested
- Standardised branded actives
- Made in the U.S.A.
- Non-GMO
And what isn't
- No caffeine or stimulants
- No added sugar
- No artificial colours or flavours
- No appetite suppressant, herbal or otherwise
- No claim to replace or reduce your prescription
Vitamin B12 (Methylcobalamin)
525mcgThe methylated form your blood already carries, at a dose set deliberately high. B12 absorption depends on stomach acid, gastric transit and animal-protein intake — all three of which change on a GLP-1 medication, and all three in the same direction.
Folate (L-5-MTHF)
400mcg DFECalcium L-5-methyltetrahydrofolate — the active form, so no conversion step, which matters because a large minority of people convert folic acid inefficiently. Folate and B12 work as a pair: run short on either and homocysteine rises.
Vitamin B6 (P-5-P)
26mgPyridoxal 5′-phosphate, pre-converted. Deliberately kept well under the 100mg upper limit — sustained high-dose B6 is one of the few genuine risks in a B-complex, and there is no good reason to go anywhere near it.
Iron (Ferrous Bisglycinate Chelate)
18mg100% of the Daily Value, chelated to glycine rather than delivered as sulfate — the form change is most of why it is less likely to sit heavily. Iron is also the one ingredient here you should not take without knowing your levels; see the warning at the foot of this section.
Zinc (Zinc Bisglycinate Chelate)
20mgChelated zinc at 182% of the Daily Value. Zinc is among the minerals most sensitive to a sudden collapse in dietary variety, and it is one of the nutrients named in the literature on shedding during rapid weight loss.
Magnesium (Oxide and Citrate)
200mgA deliberate two-form blend, and not the glycinate we use elsewhere in the range. Citrate is the better-absorbed half. Oxide is poorly absorbed on purpose — the portion that stays in the gut draws water in, which is the point when a medication has slowed everything down. If you want magnesium purely for absorption, our Magnesium Glycinate is the better bottle and we would rather say so.
Vitamin D3 (Cholecalciferol)
50mcg (2,000 IU)250% of the Daily Value. Vitamin D is the deficiency picked up most often in people on GLP-1 therapy — partly because it tracks total intake, and partly because it was already the most common shortfall before anyone started.
Biotin
5mcgPresent, and small — 17% of the Daily Value. We are not going to tell you that five micrograms of biotin is a hair-loss intervention. The zinc and the iron above are doing that work. If biotin specifically is what you are after, our Hair Skin Nails formula carries 2,500mcg.
Digestive Comfort & Soothing Blend
325mgGingerols™ ginger root extract standardised to 5% gingerols, peppermint leaf, bromelain from pineapple stem at 2,400 GDU/g, and DigeZyme® — a five-enzyme complex of α-amylase, protease, lipase, cellulase and lactase, covering starch, protein, fat, fibre and lactose respectively.
LactoSpore® Bacillus coagulans
166mg · 6 billion CFUBacillus coagulans MTCC 5856
A spore-forming probiotic, which is the whole reason it is shelf-stable: the spore passes through stomach acid dormant and germinates further down. No refrigeration, and the count on the panel is much closer to the count that actually arrives.
Energy & Vitality Complex
126mgAshwagandha root extract standardised to 5% withanolides — an adaptogen for resilience to occasional stress — together with the methylcobalamin, P-5-P and L-5-MTHF that make up the B-vitamin amounts declared above.
Nutrient Replenishment Matrix
22mgThe delivery side of the zinc, iron, biotin and vitamin D3 declared in the panel above — bisglycinate chelates for both minerals, cholecalciferol for the D3.
BioPerine® Black Pepper Extract
5mgPiper nigrum
Standardised piperine, included for absorption rather than for its own sake. Piperine has the best evidence of any common bioavailability enhancer, and iron is one of the specific nutrients it has been studied alongside.
What is on the panel
Every vitamin and mineral above is declared with an exact amount and a percentage of the Daily Value. The three blends are declared at blend level, with the total weight of each blend, every ingredient in it, and the standardisation of the branded components — Gingerols™ at 5% gingerols, bromelain at 2,400 GDU/g, LactoSpore® at 6 billion CFU, plus DigeZyme® and BioPerine®.
Before you start
GLP-1 Support is a dietary supplement. It is not a medicine, not a substitute for a GLP-1 medication, and not a substitute for medical advice. Talk to your doctor or pharmacist before taking it if you are pregnant or nursing, take prescription medication, or have a condition affecting iron storage. Iron and magnesium can both reduce the absorption of other medicines taken at the same time, so leave a couple of hours between them where you can. Do not supplement iron without knowing your levels.
WARNING: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately.
Seven papers this formula leans on.
Independent published research on individual ingredients — not trials of this product. gram has never run a clinical trial, and we would be sceptical of a supplement brand that told you otherwise.
Ginger extract for nausea — clinical trial
A multicentre, double-blind, placebo-controlled trial in 103 adults starting chemotherapy. Four standardised ginger capsules a day — 84mg of active gingerols and shogaols — beat placebo on nausea-related quality of life, delayed nausea severity and fatigue. The effect is attributed to gingerols and shogaols acting on 5-HT3 serotonin receptors in the gut, the same receptor family some prescription anti-nausea drugs target. No significant adverse events.
Why it's here: Nausea is the side effect GLP-1 users report more than any other, and it peaks around dose escalation.
Piperine as an iron absorption enhancer
A review of BioPerine® (piperine) as a thermonutrient that stimulates intestinal epithelial cells and widens the absorption window for co-administered nutrients. Serum iron concentrations ran significantly higher when iron was given with piperine than iron alone; human trials in iron-deficient participants also showed improved haemoglobin and ferritin alongside reduced fatigue scores.
Why it's here: It is why there are 5mg of black pepper extract in a formula that is otherwise about vitamins and minerals.
Magnesium and zinc in glucose regulation (2025)
A 2025 study of magnesium and zinc — given together with β-carotene alongside metformin — in aged rats with type 2 diabetes. Low magnesium and zinc status tracked with worse oxidative stress and glycaemic control, and supplementing both alongside standard treatment attenuated several diabetes-related complications.
Why it's here: Both minerals are in this formula, and both are among the first to slip when total intake falls.
Bromelain for digestive support (2024)
A 2024 study of bromelain’s dual role as a proteolytic digestive enzyme and an anti-inflammatory agent in the gastrointestinal tract. Bromelain broke down dietary proteins effectively, reducing reported discomfort and post-meal bloating, while modulating gut inflammation through cytokine inhibition. Favourable safety profile at supplemental doses.
Why it's here: Protein is the macronutrient people on a GLP-1 are most often told to prioritise and most often struggle to finish.
GLP-1 medications and hair loss — systematic review (2026)
A PRISMA systematic review of GLP-1-associated hair loss, published in 2026 after searching four databases and screening 133 studies down to 24. Semaglutide and tirzepatide showed the highest reported incidence; androgenetic alopecia and telogen effluvium were the predominant subtypes, with tirzepatide — the drug associated with the largest weight loss — most often linked to telogen effluvium. Rapid weight loss emerged as a likely contributor, and the authors are explicit that causality is not yet established.
Why it's here: Rapid weight loss means a rapidly shrinking plate, and zinc and iron are among the first nutrients to go with it. Both are in this formula at meaningful doses. Biotin, the third nutrient usually named in this context, is here at 5mcg, which is not a meaningful dose and we have said so in the ingredient list above.
B12, folate and homocysteine
A prospective observational study in patients receiving pemetrexed chemotherapy, documenting how low B12 and folate raise homocysteine — a biomarker linked to depressive symptoms, cognitive impairment and neurological toxicity. Participants with inadequate B12 and folate showed significantly higher rates of complications and depressive symptoms.
Why it's here: Both nutrients depend on regular dietary intake, and mood change is now being reported among GLP-1 side effects. Nutrient depletion is one plausible contributor among several.
Magnesium and sleep quality — randomised controlled trial (2024)
A 2024 randomised, double-blind, placebo-controlled trial in 80 adults aged 35–55 with self-reported sleep problems. Over 21 days the magnesium group held its sleep quality and daytime functioning steady while the placebo group declined, and wearable measurements showed significantly better deep sleep and REM sleep scores than placebo.
Why it's here: Appetite suppression and caloric restriction both push magnesium intake down, and poor sleep compounds the fatigue people already attribute to the medication.
Each citation describes published work on a single ingredient, at the dose used in that work — which is not always the dose used here. None of it establishes that this product will do anything in particular for you, and none of it was funded by or conducted on behalf of gram.
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Built around the gap, not around the drug.
Nothing here interacts with how a GLP-1 medication works, and nothing here is trying to. The formula addresses two consequences of eating substantially less: a digestive system running slowly, and a nutrient intake that shrank along with the plate.
525mcg
methylcobalamin B12 per serving, in the pre-methylated form
5
digestive enzymes covering starch, protein, fat, fibre and lactose
6B
CFU of shelf-stable Bacillus coagulans spores
- Step one
Take both with your largest meal
Enzymes and ginger have the most to do when there is food in front of them, and iron is easier on a stomach that isn’t empty. Once a day, whichever meal is biggest — there is no benefit to splitting the dose.
- Step two
Full amounts on the vitamins
Every vitamin and mineral is declared with a number and a percentage of the Daily Value, so you can add it to whatever else you take and check the totals.
- Step three
Keep taking it while intake is down
Nutrient status is a running balance, not a one-off correction. This is designed to be taken for as long as you are eating substantially less, which for most people means as long as the prescription lasts.
8 in 10
say it made the first month on their medication easier to sit through
Self-reported, gram customer survey, 2026. Illustrative placeholder — individual results vary, and this is not a clinical finding.
The first eight weeks, honestly.
This is a habit and tolerability timeline, not a results timeline. Bloodwork is the only thing that tells you where your nutrient status actually is, and it moves on its own schedule rather than ours.
- Days 1–7
Find the right meal
Take both capsules with whichever meal you are still eating properly. If the iron sits heavily, move it to a later meal before you consider dropping it — with this formula the timing is usually the problem, not the dose.
- Weeks 2–3
The routine attaches itself
Most people end up taking this at the same time as something they already take daily. That is the easiest habit to build, because it is already built.
- Weeks 4–6
Through the first bottle
If you have bloodwork due, this is a sensible point to ask for B12, ferritin and vitamin D. Numbers beat impressions, and they are the only way to know whether any of this is landing.
- Week 8+
Part of the protocol
By here it isn’t a decision any more. Keep going for as long as your intake is down — and make sure whoever writes your prescription knows this is in the mix.
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GLP-1 Support vs. the typical “GLP-1 companion”.
An illustrative comparison against common practice in a category that appeared almost overnight and is not, on the whole, being careful. Read the panel on whatever you are considering — including this one.
gram GLP-1 Support
- Every vitamin and mineral declared with an exact amount
- Active B-vitamin forms — methylcobalamin, L-5-MTHF, P-5-P
- Chelated iron and zinc, not oxide or sulfate
- Branded actives with published standardisation
- The FDA iron warning printed, not buried
- Says plainly what it does not do
- Third-party tested, COA published per batch
The typical GLP-1 companion
- Every vitamin and mineral declared with an exact amount
- Active B-vitamin forms — methylcobalamin, L-5-MTHF, P-5-P
- Chelated iron and zinc, not oxide or sulfate
- Branded actives with published standardisation
- The FDA iron warning printed, not buried
- Says plainly what it does not do
- Third-party tested, COA published per batch
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Back Guarantee
Sixty days. Then decide.
Take GLP-1 Support every day for 60 days. If it hasn’t earned its place next to your prescription, email us and we’ll refund the order — including bottles you’ve already opened.
We’d rather carry the risk than ask you to.
- Full refund within 60 days, opened bottles included
- No form to fill in — one email does it
- Cancel or pause a subscription any time
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What people say about GLP-1 Support
The escalation week was survivable
“These arrived the same week I stepped up my dose, which was an accident but a useful one. The first increase floored me for four days. The second one I worked through. I am not going to pretend I ran a controlled trial, but I reordered.”
My prescriber suggested this category
“Nine months in, my B12 had drifted to the bottom of the range and my energy showed it. My GP told me to find a B12 and iron supplement rather than change anything about the injection. This was the one that had both in forms I could actually tolerate.”
Finally an iron I can keep down
“Every iron tablet I have tried made me feel worse than being low did. The bisglycinate here doesn’t. That is genuinely the entire reason I stayed on it.”
Bought it for the shedding
“Four months of hair coming out after losing forty pounds. My dermatologist said telogen effluvium and told me to sort out zinc and iron. This was the only one I found with both at real amounts that wasn’t also selling me a miracle.”
The ingredient page sold me
“I went in expecting the usual marketing and found a page that explains why each ingredient is in there, including where it says one of them is in for absorption rather than for its own sake. That is not how these are usually written. Bought it on the spot.”
Questions worth asking.
Can I take this with semaglutide, tirzepatide or another GLP-1 medication?
Is this a replacement for my prescription?
Should I be taking 18mg of iron?
Do I need this if I am not on a GLP-1 medication?
When should I take it?
What does “third-party tested” actually mean here?
What if it isn’t for me?
Two capsules. Alongside, not instead.
Sixty days to decide, free shipping on every bottle, and a subscription you can pause in one click.
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